Three college students get lost in the seedy streets where they encounter a crazed gang of homeless derelicts that seizes them and one-by-one, horrifically kills all but one man. The surviving man escapes on foot, naked and unarmed, with a pack of depraved transients in pursuit, and only seconds away from capture.

After the unexplained death of their Uncle Arlo, Kayla Nunez and her sister venture to his home in the rural town of Wickenhaven. They plan to claim their share of his estate, but their trip takes a drastic turn after discovering that their uncle's house is occupied by a mysterious relative, Aunt May, who may be harboring deadly secrets. Complicating matters is the deranged, lust-filled tanning salon owner, Dale, and his exotic wife, Joan, whose business in designer handbags is the backbone to the entire town's economy, and possibly the darkest fashion controversy the world will ever know.

Friends and family pursue an estranged writer to an isolated house only to find that, once they've entered, their own fears will kill them if they leave.